The versatility to elevate therapeutics
Biopact’s XACTTM technology is tackling the unmet needs of drug delivery. By reducing toxicity, increasing stability, and improving dosing regimens, it has the ability to reinvigorate challenged R&D programs. XACT directs drugs to specific locations, thereby mitigating adverse effects, while providing control and sustained release of compounds. XACT successfully carries membrane-impenetrable payload molecules into the cell.
Additional benefits of XACT include the compatibility with a diverse range of cargo molecules, the extremely high cargo loading ratio, the shelf stability and the consistency of scalable production. XACT holds the potential to extend patent life or reposition older technology.
XACT applications to take your API to the next level:
Controlled and sustained release
XACT drug release can be controlled via surface chemistry or formulation changes. Release can be tuned, in vitro from 1 to >240 hours regardless of the drug composition. The pH can stop/slow the elution for storage or activation in a particular environment. This release design has the potential to improve safety profiles and enhance PK performance.
XACT offers the ability to deliver a drug directly to its target through the use of innate directionality or chemically-bound directing entities. XACT offers various attachment points for antibodies, signally peptides, and localized molecules. The customized applications are economical to replicate.
Intracellular peptide/protein delivery
XACT is naturally cell permeable with no additional modifications. This increased cell penetration allows for delivery of therapeutics into tissues and/or tumors. XACT can bind to a peptide is known to be cell membrane impermeable, shuttle it across the membrane, and release the peptide to trigger apoptosis.
XACT can be targeted to bone, and in early studies, the XACT and bone appear to have a potentially beneficial interaction post-bonding. This exciting discovery combined with other known features of XACT opens up the door to study XACT as a tissue and bone repair/scaffolding agent. In addition, XACT could be used to deliver various therapeutics to the regeneration site.
XACT naturally penetrates the cell and localizes in the nucleus, unlocking the potential to deliver genetic material directly to target cells.
XACT can bond with photo fluorescence for tracking and imaging in diagnostic applications, and XACT’s physical properties make it an excellent candidate to use in the latest generation of biosensors.
Devices and medical materials
XACT is strong, lightweight, flexible and conductive, making it an ideal candidate for improvement of all variety of medical materials (e.g. surgical screws, plates, rods, bio-devices). Combine this with XACT’s other potential uses, in drug delivery and biosensors, and the potential to impact a wide array of medical materials.
Vast medical applications
XACT can be customized with the potential to enable a vast number of medical applications in many fields of medicine: drug delivery, cancer, neurological disease, wound care, devices, diagnostics, stem cell, genomics, bone growth and repair, tissue regeneration, neural regeneration, bio-sensors, 3-D printing, prosthetics and orthopedics, below is a list of potential applications:
- Medical nano-robots, “smart” sensors, diagnostics and markers
- Slow elution of allergens as a prophylactic or “vaccine” treatment
- Pharmaceutical anti-counterfeiting
- Bio-imaging advancements
- Research support – tissue cultures, fused antibodies for detection and identification
- Sensors for diagnostics, disease markers
- EM shielding for medical devices
- XACT-Antibody conjugates for early disease detection
- Nanowires to direct nerve regeneration
- Nanofiltration devices
- Localized monotherapy for tumor ablation
- Wound care as an additive or in dressings