Promising assessments of intracellular delivery performance in different cell-types suggest the potential for developing MGMR® as a biomolecular delivery vehicle for diverse cell-types and expression platforms of interest to therapeutic, biomanufacturing, agricultural and industrial applications.
Robust cellular uptake observed with MGMR offers the potential to deliver molecular payloads to difﬁcult-to-penetrate cell-types or those acutely sensitive to detergents and other conventional methods for transmembrane delivery.
In a murine therapeutic model, MGMR loaded with doxorubicin (Dox) demonstrated a remarkable capability to rapidly concentrate drug in targeted tissues and extend half-life of its molecular cargo.
Excellent cytotoxicity profile
Biopact has evaluated the cytotoxicity profile of MGMR across multiple cell-lines and investigated safety and efﬁcacy in murine biodistribution and clearance models. Our in vivo studies demonstrate that MGMR is biologically-inert, well-tolerated and rapidly cleared from non-targeted tissues.
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Biopact offers a simple process to test MGMR’s delivery capability with your payload
Intracellular delivery of your biomolecule is within reach